Protein Clock

A protein clock measures results that are close to the functional end result we seek. We can compare the protein clock with, and use it alongside, other kinds of clocks.

One of the architects of an innovative system and lead author of the article below Benoit Lehallier helped me create a version of the protein clock.

I extracted data from a sample file provided by test provider SomaLogic, paired it up with the protein and coefficient data in the paper, ran 64 samples to calculate final scores for each, and plotted this graph showing a relationship between chron age and score: (Let me know if you can’t see this graph)

Lower score is associated with youth. The obvious idea is that an aging therapy would reset proteins to a more youthful state – i.e. a lower score.

This was done as a proof of concept and I don't know anything about the subjects from the sample file.

Note the two 18 year olds with low scores – but the one around age 36 is almost as low.

The two around 69 or 71 with low scores must be doing something right, or won the genome lottery.

Uh oh – the approx. 44 year old with the high score around the 70 year olds looks like one sick puppy.

I am working to overcome some obstacles to offering this to the research community, and perhaps someday to consumers.

The paper
Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging
https://onlinelibrary.wiley.com/doi/10.1111/acel.13256